By Tomohiro Kurosaki, Jürgen Wienands
This quantity info our present knowing of the structure and signaling services of the B cellphone antigen receptor (BCR) in health and wellbeing and ailment. the 1st chapters overview new insights into the meeting of BCR elements and their association at the mobilephone floor. next contributions specialize in the molecular interactions that attach the BCR with significant intracellular signaling pathways equivalent to Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. those components orchestrate cytoplasmic and nuclear responses in addition to cytoskeleton dynamics for antigen internalization. in addition, a key mechanism of ways B cells take into account their cognate antigen is mentioned intimately. Altogether, the discoveries awarded offer a greater knowing of B mobile biology and support to provide an explanation for a few B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cellphone tumors, whereas additionally paving the best way for finally scuffling with those diseases.
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Extra resources for B Cell Receptor Signaling
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Earlier studies with B cells expressing both isotypes of BCR showed that stimulation with one type of anti-HC antibodies induces phosphorylation of only the Igα associated with the corresponding BCR (Gold et al. 1991; Schamel and Reth 2000). This suggests that IgM-BCR and IgD-BCR may be physically separated from each other. Recent Fab-PLA studies have shown that during BCR activation, IgD-BCR loses its proximity to the coreceptor molecules CD19/CD20 and the GM-1 ganglioside, while IgM-BCR gains proximity toward these molecules.
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B Cell Receptor Signaling by Tomohiro Kurosaki, Jürgen Wienands