B Cell Receptor Signaling by Tomohiro Kurosaki, Jürgen Wienands PDF

By Tomohiro Kurosaki, Jürgen Wienands

ISBN-10: 3319261312

ISBN-13: 9783319261317

ISBN-10: 3319261339

ISBN-13: 9783319261331

This quantity info our present knowing of the structure and signaling services of the B cellphone antigen receptor (BCR) in health and wellbeing and ailment. the 1st chapters overview new insights into the meeting of BCR elements and their association at the mobilephone floor. next contributions specialize in the molecular interactions that attach the BCR with significant intracellular signaling pathways equivalent to Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. those components orchestrate cytoplasmic and nuclear responses in addition to cytoskeleton dynamics for antigen internalization. in addition, a key mechanism of ways B cells take into account their cognate antigen is mentioned intimately. Altogether, the discoveries awarded offer a greater knowing of B mobile biology and support to provide an explanation for a few B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cellphone tumors, whereas additionally paving the best way for finally scuffling with those diseases.

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Blood 111(3):1396–1403 Ma S, Pathak S, Mandal M, Trinh L, Clark MR, Lu R (2010) Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Mol Cell Biol 30(17):4149–4158 Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129 (7):1261–1274 Marshall AJ, Fleming HE, Wu GE, Paige CJ (1998) Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J Immunol 161(11):6038–6045 Meixlsperger S, Kohler F, Wossning T, Reppel M, Muschen M, Jumaa H (2007) Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor.

Earlier studies with B cells expressing both isotypes of BCR showed that stimulation with one type of anti-HC antibodies induces phosphorylation of only the Igα associated with the corresponding BCR (Gold et al. 1991; Schamel and Reth 2000). This suggests that IgM-BCR and IgD-BCR may be physically separated from each other. Recent Fab-PLA studies have shown that during BCR activation, IgD-BCR loses its proximity to the coreceptor molecules CD19/CD20 and the GM-1 ganglioside, while IgM-BCR gains proximity toward these molecules.

Nat Rev Immunol 10:767–777 Puffer EB, Pontrello JK, Hollenbeck JJ, Kink JA, Kiessling LL (2007) Activating B cell signaling with defined multivalent ligands. ACS Chem Biol 2:252–262 Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger PD, Stutzman N, Pierce SK, Sun PD (2010) Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. Structure 18:934–943 Reth M (1989) Antigen receptor tail clue. Nature 338:383–384 Reth M (1992) Antigen receptors on B lymphocytes.

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B Cell Receptor Signaling by Tomohiro Kurosaki, Jürgen Wienands


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