Get Biological Characterization of Bone Tumors PDF

By G. C. Steiner (auth.), A. Roessner (eds.)

ISBN-10: 3642744621

ISBN-13: 9783642744624

ISBN-10: 3642744648

ISBN-13: 9783642744648

During the prior few years, various monographs on bone tumors were released. they're customarily limited to bone tumors as clinical-pathological entities, for the reason that their prognosis, greater than that of different tumors, calls for the interdisciplinary cooperation among orthopedic expert, radiologist, and pathologist. even though, investiga­ tions about the histogenesis of bone tumors are really constrained, even though they may be priceless in explaining the original morphological heterogeneity of tumors of the skeletal procedure. additionally, the histo­ genetic strategy within the learn of bone tumors may perhaps facilitate the inter­ pretation of the complex cytobiological equipment to be had for improv­ ing category and analysis. accordingly, this quantity provides contemporary pathological advances within the organic characterization of bone tumors. an enormous bankruptcy bargains with the differential prognosis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The research of the floor ingredients in bone-forming tumors can be priceless for his or her class. accordingly the quantity encompasses a bankruptcy at the biochemical and histochemical research of alternative osteosarcoma kinds. lately it has develop into transparent that during addition to assorted collagen forms which aren't particular for bone tissue, a number of bone-specific proteins happen, one in all that is osteonectin. Its distribu­ tion is clearly very important for the type and analysis of osteo­ blastic tumors. Proliferative habit is of significant significance for the prognosis of malignant tumors.

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Histological and Biochemical Analyses of Osteosarcomas Morphological and Histological Description of Large Tumor Samples . Biochemical Data . . . . . . . . . Zonal Combined Biochemical and Histological Analyses. Zonal Morphological and Histological Characterization . Zonal Biochemical Characterization . . . . . Comparison of Hard Tissue Formation in Osteosarcomas with Physiological Bone Formation . References. . . . . . . . . . . . . . . . . . . 55 56 56 58 61 66 66 67 67 70 77 77 79 84 88 1 Introduction Generally osteosarcomas show a pattern of considerable heterogeneity.

Although usually absent, glycogen can occasionally be identified. There is another small group of un differentia ted small cell sarcomas that lack any specific characteristic either by immunohistochemistry or electron microscopy. They are referred to as sarcomas of undetermined histogenesis (ERLANDSON 1987). 6 Conclusions In this study of small round cell tumors of bone, the techniques of immunohistochemistry and electron microscopy were evaluated with the purpose of differentiating Ewing's sarcomas from neuroectodermal tumors.

11). 4. Non-Bane-Forming Skeletal Tumors All other investigated skeletal tumors were negative. None of the Ewing's sarcomas showed a positive tumor cell reaction. The chondromatous tumors were likewise negative but presented a special feature: Whereas the chondromatous tumor portions were also completely negative, single positively reacting cells located near the mineralization zones were seen in the chondroblastoma segments that consisted in part of fibroblastic spindle-shaped cells. The immediately adjacent multinucleated osteoclastic giant cells were negative.

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Biological Characterization of Bone Tumors by G. C. Steiner (auth.), A. Roessner (eds.)


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