By Larry V McIntire; World Technology Evaluation Center.; et al
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Extra resources for WTEC panel on tissue engineering research : final report
2000. Use of bone-bonding hydrogel copolymers in bone: An in vitro and in vivo study of expanding PEO-PBT copolymers in goat femora. J. Biomed. Mat. Res. 49:312-318. , H. Alexander, et al. 1992. Biologic response of intramedullary bone to poly-l-lactic acid. In Tissue-Inducing Biomaterials. G. ). Pittsburgh, Materials Research Society. 252:339-343. C. 1991. Body-absorbable osteosynthesis devices. Clin. Mater. 8(1-2):119-23. , I. Martin, B. Obradovic, S. J. Grodzinsky, R. E. Freed. 1999. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage.
Although some tissues, particularly bone, can tolerate very slowly degrading or permanent materials of specific compositions, permanent implants almost always elicit a chronic inflammation called a foreign body response (Anderson 1988; Babensee, Anderson, et al. 1998; Anderson and Langone 1999). This response is characterized by formation of a poorly vascularized fibrous layer analogous to a scar at the material-tissue interface. Materials and their degradation products must also be nontoxic and non-immunogenic upon implantation.
Activity in both Europe and Japan in the general area of tissue engineering is increasing due to an increased level of government funding. The funding is often directed at building interdisciplinary centers of competence such as at Tsukuba and Manchester and often has incentives or requirements for technology transfer. In Europe, but less so in Japan, technology is being transferred to industry, often through start-up companies associated with academic research centers. , medicine-) driven approaches to regenerating tissues.
WTEC panel on tissue engineering research : final report by Larry V McIntire; World Technology Evaluation Center.; et al